Bone microarchitecture and bone turnover in hepatic cirrhosis
نویسندگان
چکیده
منابع مشابه
Paradoxical Response to Mechanical Unloading in Bone Loss, Microarchitecture, and Bone Turnover Markers
BACKGROUND Sclerostin, encoded by the SOST gene, has been implicated in the response to mechanical loading in bone. Some studies demonstrated that unloading leads to up-regulated SOST expression, which may induce bone loss. PURPOSE Most reported studies regarding the changes caused by mechanical unloading were only based on a single site. Considering that the longitudinal bone growth leads to...
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The hip fracture is one major clinical challenge associated with osteoporosis, resulting in heavy socioeconomic burdens and high mortality. Systemic therapies of anti-osteoporosis drugs are expensive, time-consuming and also evoke substantial side effects, which fails to provide early protection from fractures. Accumulating evidence demonstrates the high bioavailability and therapeutic efficacy...
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We develop and evaluate a novel 3D computational bone framework, which is capable of enabling quantitative assessment of bone micro-architecture, bone mineral density and fracture risks. Our model for bone mineral is developed and its parameters are estimated from imaging data obtained with dual energy x-ray absorptiometry and x-ray imaging methods. Using these parameters, we propose a proper 3...
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Aims Renal Osteodystrophy (ROD) is a systemic disorder that develops early with loss of kidney functions and is manifested by abnormalities in bone metabolism, mineralization and volume. Phosphate binders are a major constituent in chronic kidney disease management. Previous Aluminum and calcium containing phosphate binders were thought to be of detrimental effect on bone histology. The aim of ...
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Bone has the ability to adapt its shape and size in response to mechanical loads via a process known as modelling in which bones are shaped or reshaped by the independent action of osteoblasts and osteoclasts. Remodelling is a process that maintains mechanical integrity of the skeleton, allowing it to selectively repair and replace damaged bone. During adulthood, bone remodelling is the dominan...
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ژورنال
عنوان ژورنال: Osteoporosis International
سال: 2019
ISSN: 0937-941X,1433-2965
DOI: 10.1007/s00198-019-04870-6